Estimation of human absorbed dose for 166Ho-PAM: comparison with 166Ho-DOTMP and 166Ho-TTHMP
نویسندگان
چکیده
منابع مشابه
Human organ absorbed dose estimation of 166Ho-BPAMD complex based on biodistribution data of male Syrian rats
Introduction: Recently, 166Ho-BPAMD was introduced as a suitable agent for bone marrow ablation. The aim of this study was to estimate the absorbed dose of this novel agent in the human organs which is necessary before the clinical application. Methods: 166Ho was produced by direct irradiation of 165Ho in the research reactor. 250 µg...
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Background: Skin cancer can be treated by various methods. Electron radiotherapy has been a useful therapeutic modality in the treatment of skin cancers in areas which are difficult to cure by other methods. Depth dose distribution of 166Ho using VARSKIN2 code is presented in this work. Material and Methods: Depth dose distribution of 166Ho was calculated, using VARSKIN2 code by adding...
متن کاملSafety of a Scout Dose Preceding Hepatic Radioembolization with 166Ho Microspheres.
UNLABELLED Before (166)Ho radioembolization, a small batch of the same type of microspheres is administered as a scout dose instead of the conventional (99m)Tc-macroaggregated albumin ((99m)Tc-MAA). The (166)Ho scout dose provides a more accurate and precise lung shunt assessment. However, in contrast to (99m)Tc-MAA, an unintended extrahepatic deposition of this β-emitting scout dose could infl...
متن کاملProduction and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
متن کاملPreclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma
Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...
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ژورنال
عنوان ژورنال: The British Journal of Radiology
سال: 2016
ISSN: 0007-1285,1748-880X
DOI: 10.1259/bjr.20160153